2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W019726S1
    Dehydro Nifedipine-13C,d3
    Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies.
    Dehydro Nifedipine-<sup>13</sup>C,d<sub>3</sub>
  • HY-W001080S1
    3,4-Dihydroxybenzeneacetic acid-d3
    3,4-Dihydroxybenzeneacetic acid-d3 is deuterium-labeled 3,4-Dihydroxybenzeneacetic acid (HY-W001080).
    3,4-Dihydroxybenzeneacetic acid-d<sub>3</sub>
  • HY-161481
    Melamine/bov igG
    Melamine/bov igG is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Melamine/bov igG
  • HY-78841S
    (2S,4S)-Sacubitril-d4
    (2S,4S)-Sacubitril-d4 is deuterium labeled (2S,4S)-Sacubitril. (2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure.
    (2S,4S)-Sacubitril-d<sub>4</sub>
  • HY-121252S
    Dopal-d5
    Dopal-d5 is the deuterium labeled Dopal (HY-121252). Dopal is a metabolite and aldehyde neurotoxin of Dopamine (HY-B0451). Dopal exhibits cytotoxicity, induces α-synuclein oligomerization and aggregation, and is closely associated with the pathogenesis of Parkinson's disease. Dopal can be used in research related to Parkinson's disease.
    Dopal-d<sub>5</sub>
  • HY-33914R
    4-Hydroxymethylpyrazole (Standard)
    4-Hydroxymethylpyrazole (Standard) is an analytical standard for 4-Hydroxymethylpyrazole (HY-33914). This product is intended for research and analytical applications. 4-Hydroxymethylpyrazole is the primary metabolite of fomepizole (HY-B0876) via hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole inhibits alcohol dehydrogenase (ADH) in humans and monkeys, but the inhibition constant is much higher than that of fomepizole and is therefore negligible in vivo
    4-Hydroxymethylpyrazole (Standard)
  • HY-143968S
    Ketotifen impurity 3-d4
    Ketotifen impurity 3-d4 is the deuterium labeled Ketotifen impurity 3.
    Ketotifen impurity 3-d<sub>4</sub>
  • HY-12771S1
    O-Desmethyl mebeverine acid-d5 (hydrochloride)
    O-desmethyl Mebeverine acid-d5 (hydrochloride) is the deuterium labeled O-desmethyl Mebeverine acid.
    O-Desmethyl mebeverine acid-d<sub>5</sub> (hydrochloride)
  • HY-12770S
    Mebeverine alcohol-d5
    		≥98.0%
    Mebeverine alcohol-d5 is the deuterium labeled Mebeverine alcohol, which is a metabolite of Mebeverine.
    Mebeverine alcohol-d<sub>5</sub>
  • HY-W344074
    Cytarabine 5’-monophosphate
    		98.04%
    Cytarabine 5′-monophosphate is a metabolite of the nucleoside analog Cytarabine (HY-13605), catalyzed by deoxycytidine kinase. Cytarabine 5′-monophosphate is incorporated into DNA by DNA polymerase α, which reduces the rate of DNA synthesis. At a concentration of 15 mM, Cytarabine 5′-monophosphate inhibits nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae (S. cerevisiae). Additionally, Cytarabine 5′-monophosphate (3.5-75.1 mg/kg) improves survival in leukemia mice (L1210 mice). Cytarabine 5′-monophosphate can be used in cancer research.
    Cytarabine 5’-monophosphate
  • HY-G0021S1
    N-Desmethylclozapine-d8 hydrochloride
    		99.74%
    N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist.
    N-Desmethylclozapine-d<sub>8</sub> hydrochloride
  • HY-133676S
    Mono(2-ethyl-5-oxohexyl) phthalate-d4
    Mono(2-ethyl-5-oxohexyl) phthalate-d4 is a deuterium labeled Mono(2-ethyl-5-oxohexyl) phthalate (HY-133676). Mono(2-ethyl-5-oxohexyl) phthalate is an oxidative metabolite of Di(2-ethylhexyl) phthalate (DEHP). Mono(2-ethyl-5-oxohexyl) phthalate may protective sperm DNA damage. Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(2-ethyl-5-oxohexyl) phthalate-d<sub>4</sub>
  • HY-118010B
    (-)-Norfenfluramine
    (-)-Norfenfluramine (l-Norfenfluramine) is a Fenfluramine metabolite. (-)-Norfenfluramine effectively counteracts the zebrafish abnormal locomotor activity. (-)-Norfenfluramine can be used in epilepsy research.
    (-)-Norfenfluramine
  • HY-135392R
    N-Desmethyl Pimavanserin (Standard)
    Methyl 3,4-dihydroxybenzoate (Standard) is the analytical standard of Methyl 3,4-dihydroxybenzoate. This product is intended for research and analytical applications. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect.
    N-Desmethyl Pimavanserin (Standard)
  • HY-N16449
    Arachidonoylmorpholine
    Arachidonoylmorpholine is a metabolic regulatory molecule related to arachidonic acid metabolism. The level of Arachidonoylmorpholine will increase when the function of the intestinal flora is disrupted. Arachidonoylmorpholine is promising for research of pig gut health, such as post-weaning diarrhea (PWD) in piglets.
    Arachidonoylmorpholine
  • HY-B0602S
    (R)-(-)-O-Desmethyl Venlafaxine-d6
    (R)-(-)-O-Desmethyl Venlafaxine-d6 is the deuterium labeled (R)-(-)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
    (R)-(-)-O-Desmethyl Venlafaxine-d<sub>6</sub>
  • HY-W701814
    Mazindol metabolite-d4 hydrochloride
    Mazindol metabolite-d4 hydrochloride is the deuterium labeled 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride (HY-W700741). 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one hydrochloride is a metabolite of the anorectic agent Mazindol.
    Mazindol metabolite-d<sub>4</sub> hydrochloride
  • HY-157910
    (±)17(18)-EpETE methyl ester
    (±)17(18)-EpETE methyl ester is an analog of the eicosapentaenoic acid (EPA) metabolite (±)17(18)-EpETE.
    (±)17(18)-EpETE methyl ester
  • HY-108869R
    Fodipir (Standard)
    Malvidin (chloride) (Standard) is the analytical standard of Malvidin (chloride). This product is intended for research and analytical applications. Malvidin (chloride) is a bioactive compound isolated from grape. Malvidin shows cytotoxicity through the arrest of the G2/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer.
    Fodipir (Standard)
  • HY-W1122284
    5,6-Epoxy-β-ionone
    5,6-Epoxy-β-ionone, a derivative of β-ionone (HY-W015084), is a metabolite of Canthaxanthin (HY-B1960).
    5,6-Epoxy-β-ionone
Cat. No. Product Name / Synonyms Application Reactivity